Analytical Techniques

• Liquid Chromatography 
Identification, assay and impurity profiling of chemical entities. High or ultrahigh performance liquid chromatography coupled to ultraviolet/visible, refractive index or mass spectrometry detection. 
• Gas chromatography 
Gas chromatography with flame ionization detection for residual solvent analysis, and for identification, assay and impurity profiling of volatile chemical entities. 
• Thin layer Chromatography 
Identification of chemical entities and their impurities, in simple and complex matrices. 

• Ultraviolet and visible spectrophotometry 
Identification and assay of chemical entities. 
• Infrared spectrophotometry 
Identification of chemical entities by FTIR with transmission or absorption recording. 
 

• Titrimetry 
Assay by amperometric, potentiometric or complexometric titration. 
• Water Content 
Coulometry and Karl Fischer titration. 
• Loss on drying 
• Identification reactions of ions and functional groups 
• Potentiometric determination of pH 
• Clarity and degree of opalescence of liquids 
• Degree of coloration of liquids 
• Osmolarity 
• Relative density 
• Refractive index 
• Optical rotation 

• Disintegration 
For tablets, capsules, suppositories and pessaries. 
• Unity of dosage units 
• Dissolution test 
Dissolution rate for conventional-, prolonged- or delayed-release solid dosage forms with a basket or paddle apparatus. 
• Friability 
• Resistance to crushing 

• Sterility 
Membrane filtration or direct inoculation. 
• Microbiological examination of non-sterile products  
Microbial enumeration is applied to quantify aerobic bacteria and fungi. The presence of specific micro-organisms is tested by growth on an appropriate medium and under specific conditions. Automated microbial identification based on biochemical testing. 
• Bacterial endotoxins 
Detection and quantification by the gel-clot or chromogenic method. 
• Assay of heparins 
Determination of the anticoagulant activity of heparins. 

• Micro- and macroscopy 
Identification and foreign matter. 
• Liquid chromatography 
Identification and assay of active substances and markers. High or ultrahigh performance liquid chromatography coupled to ultraviolet/ visible, fluorescence, refractive index or mass spectrometry detection. 
• Gas chromatography 
Chromatographic profile of essential oils. 
• Thin-layer chromatography 
Identification of active substances and markers. 
• Ultraviolet and visible spectrophotometry 
Colorimetry of active substances and markers. 
• Determination of essential oils 
• Microbiological examination 
Microbiological enumeration and testing for specified micro-organisms in herbal medicinal products for oral use and extracts. 

The list of our accredited techniques is available on request or can be consulted here.